I am super impressed by these things, and others. I still mean to explore Angular more, as I was previously excited by it. I am pretty sure Ember is my way forward. Backbone was awesome for its time, but on to Ember!

I am interested in integrating with TypeScript for static typed foundation, and a module loading system (perhaps AMD), doing some static analysis on the statically typed code, blending with some magic sauce, and then serving it all up using Node. I feel this would be pretty comparable to Go and perhaps easier to transition to from people with existing Node investments.
Update: TypeScript has support for external definitions of existing JS files; the DefinitelyTyped project provides them for many major projects including Bootstrap and Ember!